BACMAM LRRK2 REAGENT

BacMam LRRK2 Reagent

Description

BacMam LRRK2 Wild Type Reagent is a modified insect cell virus (baculovirus) that enables easy, efficient, and titratable overexpression of full-length wild-type LRRK2 in your choice of cellular background, including primary neurons and neuroblastoma cell lines.

BacMam LRRK2 Wild Type Reagent Lets You:

• Easily overexpress full-length LRRK2 in most cellular backgrounds
• Conduct the LRRK2 cellular assays you need
• Understand the effects of therapeutically relevant LRRK2 mutations

Examine LRRK2 Mutations with BacMam Reagents
Use therapeutic mutant reagents G2019S (Cat. no. A13389) and D1994A (Cat. no. A13390) along with the wild-type LRRK2 reagent to enable your research into LRRK2 mutations, including exploration of differences in cellular response to stimulus among different mutations.

Expand Your Battery of Cellular Assays for LRRK2
Once full length LRRK2 has been introduced into your cellular background, the transduced cells allow you the flexibility to conduct many types of LRRK2 experiments, including studies of regulation of physiologically functional pathways (including signaling pathways leading to function), and identification of potential physiological substrates for LRRK2.

Overexpress Full-Length LRRK2 in Most Mammalian Cell Backgrounds
BacMam technology utilizes a modified baculovirus to deliver and express genes in mammalian cells with minimal effort and toxicity. It enables efficient, titratable LRRK2 protein expression in various mammalian cellular backgrounds, including cell lines that may not be compatible with traditional transfection methods, such as primary neurons and neuroblastoma cell lines.

For research use only. Not intended for any human or animal therapeutic or diagnostic use.

Specifications

Cell State:	Cells Not Included
Delivery Method:	Baculovirus (BacMam System)
Druggable Target:	Kinases
Gene Symbol:	LRRK2
Human Protein Class:	Kinases
Product Size:	15 ml
Shipping Condition:	Wet Ice

Contents & storage

Recombinant baculovirus particles suspended in Gibco® Sf-900™ III SFM media (Cat# 12658) supplemented with 3% heat-inactivated fetal bovine serum (hiFBS) (Cat# 10100). Store at 4°C, keep sterile, protect from light, DO NOT freeze, aliquot upon arrival.

Note:
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